Controlled release enteric soft capsules of fumarate esters
AssigneeBanner Life Sciences LLC
InventorsTatyana Dyakonov, Sunil Agnihotri, Aqeel A. Fatmi
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Abstract
Described herein are pharmaceutical compositions comprising fumarate esters, methods for making the same, and methods for treating subjects in need thereof. In particular, oral pharmaceutical compositions comprising controlled release enteric soft capsules and matrices comprising fumarate esters are described.
Claims24
1-154. (canceled)
An oral pharmaceutical composition comprising one or more fumarate esters suspended in a matrix comprising a lipid or lipophilic vehicle at a weight ratio of fumarate ester to matrix from about 1:1 to about 1:5.
A method for manufacturing an oral pharmaceutical composition comprising:
- (i) providing a lipid or lipophilic matrix fill comprising a suspension of one or more fumarate esters at a weight ratio of fumarate ester to matrix from about 1:1 to about 1:5;
- (ii) providing an soft capsule shell composition;
- (iii) casting the soft capsule shell composition into films using heat-controlled drums or surfaces;
- and
- (iv) forming a soft capsule comprising the lipid or lipophilic matrix fill using rotary die encapsulation technology.
Dependencies are inferred from the claim text.