Mucoadhesive devices for delivery of active agents
AssigneesEntrega, Inc., The Regents of the University of California
InventorsBaruch Z. HARRIS, Vijay M. K. MURTHY, David Adam STEINBERG, Rodney PEARLMAN, Howard Brian ROSEN, Robert Samuel LANGER, Hila ESPTEIN-BARASH, Jonathan Robert BEHR, Samir Suresh MITRAGOTRI
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Abstract
Described herein are systems and methods for transmucosal delivery of active agents. In some embodiments, a system may comprise one or more mucoadhesive devices configured for release of an active agent.
Claims18
A polymeric controlled release preparation, comprising:
- a mucoadhesive layer comprising a first region and a second region, the first region being substantially surrounded by the second region;
- wherein
- the first region comprises an active agent;
- and
- the second region comprises a mucoadhesive material.
(canceled)
(canceled)
A pharmaceutically acceptable polymeric controlled release device for oral drug delivery, comprising:
- a mucoadhesive coating;
- and
- a polymeric release layer comprising an active agent, wherein the polymeric release layer is disposed on the mucoadhesive coating;
- and wherein the mucoadhesive coating is capable of adhering to a mucosa with a force between 2 and 30 times the weight of the device.
-24. (canceled)
A polymeric controlled release device, comprising:
- an active agent,
- a mucoadhesive layer, and
- a permeation enhancer, wherein when a surface of the device adheres to a mucosa defining a privileged region, a substantial majority of the permeation enhancer is maintained within the privileged region.
-145. (canceled)
Dependencies are inferred from the claim text.