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AssigneesYale University, Universtiy of Iowa Research Foundation
InventorsERIN LAVIK, JAMES BERTRAM, SANDEEP SALUJA, MARKUS KUEHN, JOHN J. HUANG, REBECCA ROBINSON, YOUNG H. KWON
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Biodegradable polymeric microparticle compositions containing one or more active agents, especially those useful for treating or preventing or one or more diseases or disorders of the eye, and methods of making and using thereof, are described. The microsphere compositions release an effective amount of the one or more active agents for a period greater than 14 days in vivo, preferably greater than 60 days in vivo, more preferably up to 73 days in vivo, more preferably greater than 90 days in vivo, even more preferably over 100 days in vivo, and most preferably greater than 107 days in vivo. In a preferred embodiment, the microparticle compositions contain one or more active agents such as AG1478 to induce nerve regeneration, specifically regeneration of the optic nerve useful for managing elevated intraocular pressure (IOP) in the eye.
A biodegradable injectable polymeric microparticulate pharmaceutical composition for delivery of a poorly water-soluble active agent,
A method for administering a poorly water soluble active agent, comprising administering to a site in an individual a biodegradable polymeric microparticulate pharmaceutical composition for delivery of the active agent,
Dependencies are inferred from the claim text.