Ophthalmic nanoemulsion composition containing cyclosporine and method for preparing same

An ophthalmic nanoemulsion composition, comprising:

• cyclosporine in the amount of 0.02 to 0.3 w/v % based on the total amount of the composition;
• one or more nonaqueous solvents in the amount of 0.1 to 2.5 w/v % based on the total amount of the composition selected from the group consisting of vegetable oils, C14-C20 fatty acid esters and C6-C12 fatty acid esters of glycerol;
• one or more hydrophilic emulsifiers in the amount of 0.1 to 5.0 w/v % based on the total amount of the composition selected from the group consisting of polyoxyethylene hydrogenated castor oils, polyoxyethylene sorbitan fatty acid esters, polyoxyethylene fatty acid esters and polyoxyl 35 castor oil;
• one or more hydrophobic emulsifiers in the amount of 0.1 to 5.0 w/v % based on the total amount of the composition selected from the group consisting of sorbitan fatty acid esters, glycerin fatty acid esters, diethylene glycol monoethyl ether, polyethylene glycols, propylene glycol and propylene glycol esters of fatty acids;
• and
• an aqueous solvent,
• wherein the composition has an average particle size range of 1 nm to 100 nm.

An ophthalmic nanoemulsion composition, comprising:

• cyclosporine in the amount of 0.02-0.3 w/v % based on the total amount of the composition;
• castor oil in the amount of 8 times or more of the amount of the cyclosporine to 2.5 w/v % or less based on the total amount of the composition;
• one or more hydrophilic emulsifiers selected from the group consisting of polyoxyethylene hydrogenated castor oils, polyoxyethylene sorbitan fatty acid esters, polyoxyl 35 castor oil and polyoxyethylene fatty acid esters;
• one or more hydrophobic emulsifiers selected from the group consisting of sorbitan fatty acid esters, glycerin fatty acid esters, diethylene glycol monoethyl ether, polyethylene glycols, propylene glycol and propylene glycol esters of fatty acids;
• and
• an aqueous solvent.