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US 2016/0101049 A1Published application
Method for improving the pharmaceutic properties of microparticles comprising diketopiperazine and an active agent
AssigneeMannKind Corporation
InventorsBryan R. Wilson, Marshall Grant
Life of this patent
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Abstract
Methods are provided for drying a particle. Specifically, there is provided a spray-dried diketopiperazine-insulin particle formulation having improved aerodynamic performance and in which the active agent is more stabile and efficiently delivered as compared to that of the lyophilized diketopiperazine-insulin formulation. The dry powders have utility as pharmaceutical formulations for pulmonary delivery.
Claims25
A method for forming a dry powder medicament with an improved pharmaceutic property, comprising
- a) a step for forming microparticles comprising a diketopiperazine with acidic or basic side chains, resulting in a suspension of microparticles of the diketopiperazine with acidic or basic side chains in a solvent, and optionally a step for loading said microparticles with an active agent, then
- b) removing solvent by spray drying to obtain a dry powder, wherein the dry powder has an improved pharmaceutic property as compared to a dry powder obtained by removing solvent by lyophilization, and wherein the improved pharmaceutic property is increased density of the powder, increased aerodynamic performance of the powder, or improved stability of the active agent, if present.
Dependencies are inferred from the claim text.