+l-carnosine zinc formulations and methods of use
OwnerRichard J. Di Rocco, Dale M. Lombardiinventors
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Abstract
Various formulations of L-carnosine zinc (L-CAZ), and methods of using and administering such formulations to patients suffering from various diseases, disorders, or conditions are disclosed. In particular, low average particle size L-carnosine zinc is employed in various pharmaceutical compositions, including aqueous matrices and hydrogels.
Claims21
A pharmaceutical composition comprising:
- L-carnosine zinc in an aqueous matrix of one or more pharmaceutically acceptable polymers;
- wherein the L-carnosine zinc is present at an average particle size of about 0.1μ, to about 2μ.
A method of treating the gastrointestinal mucosa, comprising:
- administering a composition comprising a plurality of L-carnosine zinc particles in an aqueous hydrogel matrix directly to a wound site, ulcer, or site of inflammation on the gastrointestinal mucosa.
A method of treating the oropharyngeal mucosa, comprising:
- administering a composition comprising a plurality of L-carnosine zinc particles in an aqueous matrix directly to a wound site on the oropharyngeal mucosa.
A method of treating disorders of the upper gastrointestinal tract, the method comprising:
- contacting the upper gastrointestinal tract of a patient in need of such treatment with a composition comprising a plurality of L-carnosine zinc particles.
A method for treating a wound site in a mucosa, comprising:
- causing carbonyl trapping activity of the L-carnosine moiety within intra-molecular atomic scale proximity to a zinc moiety at the site of mucopathy by administering a composition comprising a plurality of L-Carnosine zinc particles in an aqueous matrix to a patient in need of such treatment.
A method for enhancing gastroesophageal H. pylori eradication in the treatment of a stomach cancer patient comprising:
- administering an L-carnosine zinc composition having an average particle size of about 0.1μ, to about 2μ, to a patient in need thereof.
A pharmaceutical composition comprising:
- L-carnosine zinc particles having an average particle size of about 0.1μ, to about 2μ.
Dependencies are inferred from the claim text.