Long-lasting injectable drug releasing gel composition and method of manufacturing the same
AssigneeNational Chiao Tung University
InventorsDean-Mo LIU, Hao-Syun CHOU, Meng-Hsuan HSIAO, Yi-Chieh CHEN
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Abstract
A gel composition and method of manufacturing the same is discussed. The gel composition includes a plurality of chitosan spheres, an alkaline chitosan stabilizing agent, a chitosan decomposition enzyme and a drug. The chitosan spheres are formed by chitosan self-assembly. The alkaline chitosan stabilizing agent connects the chitosan spheres to form a gel body. The chitosan decomposition enzyme scatters in the gel body and decomposes the gel composition at a temperature of 20 to 40 degree Celsius. The drug scatters in the gel body.
Claims15
A gel composition, comprising:
- a plurality of chitosan spheres, each of the chitosan spheres being self-assembled by chitosan;
- an alkaline chitosan stabilizing agent connecting the chitosan spheres to form a gel body;
- a chitosan decomposition enzyme scattering in the gel body;
- and
- a drug scattering in the gel body,
- wherein the chitosan decomposition enzyme decomposes the gel composition at a temperature of 20 to 40 degree Celsius.
A method of manufacturing gel composition, comprising:
- preparing a chitosan solution having a concentration of 1 to 10% (w/v), solubilizing chitosan in a solvent, the chitosan self-assembling into a plurality of chitosan spheres in the solvent;
- at a temperature of 4 to 10 degree Celsius, adding a drug to the chitosan solution to form a first solution;
- and
- adding and mixing an alkaline chitosan stabilizing agent and a chitosan decomposition enzyme to the first solution, the alkaline chitosan stabilizing agent connecting the chitosan spheres, solidifying the first solution to form the gel composition, wherein a concentration of the chitosan stabilizing agent in the gel composition is 0.1 to 10% (w/v), and the chitosan decomposition enzyme decomposes the gel composition at a temperature of 20 to 40 degree Celsius.
The method of claim 10, wherein the drug is insulin, insulin sensitizer, sulfonylurea or a combination thereof. 13, The method of claim 12, wherein a concentration of the drug in the gel composition is 0.1 to 10 mg/mL.
Dependencies are inferred from the claim text.