Transscleral drug delivery
OwnerZeynab Mousavikhamene, Mohammad Jafar Abdekhodaie +1inventors
InventorsZeynab Mousavikhamene, Mohammad Jafar Abdekhodaie, Hamid Ahmadieh
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Abstract
Magnetic drug-loaded polymeric particles are used in a transscleral drug delivery method. In the synthesis process of the aforementioned magnetic drug-loaded polymeric particles, therapeutic agents, along with a magnetic agent are encapsulated in a polymer. The aforementioned magnetic drug-loaded particles can be placed near the outer surface of the sclera, and then a magnetic field can be applied in front of the eye to pull these magnetic drug-loaded particles to the outer surface of the sclera, where these particles adhere to the outer surface of the sclera and thus, the orbital clearance of the particles is eliminated or reduced.
Claims20
A method for transscleral drug delivery, the method comprising steps of:
- placing magnetic drug-loaded polymeric particles in a posterior segment of an eye, near an outer surface of a sclera;
- and
- applying a magnetic field in front of the eye to pull the magnetic drug-loaded polymeric particles closer to the outer surface of the sclera.
A method comprising:
- injecting magnetic drug-loaded polymeric particles in a posterior segment of an eye, near an outer surface of a sclera, wherein the magnetic drug-loaded polymeric particles include a therapeutic agent and a magnetic agent encapsulated in a polymer;
- and
- applying a magnetic field in front of the eye to bring the magnetic drug-loaded polymeric particles in direct contact with outer surface of the sclera to reduce clearance of particles from periocular route and deliver a therapeutically effective amount of the therapeutic agent to the eye for an extended period.
A method comprising injecting magnetic drug-loaded polymeric particles in a posterior segment of an eye, near an outer surface of a sclera, wherein:
- the magnetic drug-loaded polymeric particles include a therapeutic agent and a magnetic agent encapsulated in a bio-adhesive polymer, and
- the magnetic drug-loaded polymeric particles are configured to respond to a magnetic field due to a presence of the magnetic agent and as a result being pulled closer to the outer surface of the sclera and to adhere to the outer surface of the sclera due to a presence of the bio-adhesive polymer acting as a carrier for the magnetic drug-loaded polymeric particles.
Dependencies are inferred from the claim text.