Peptide with anti-aging effect and use thereof
AssigneeOsaka University
InventorsHironori Nakagami, Ryuichi Morishita, Hideki Tomioka, Akiko Tenma
Life of this patent
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Abstract
An object of the present invention to discover a short peptide having an anti-aging effect and to provide a novel anti-aging agent comprising the peptide as an active ingredient. The inventors have discovered that a peptide consisting of an amino acid sequence ELKLIFLHRLKRLRKRLKRK (SEQ ID NO: 1) or a partial sequence thereof and having one or more effects selected from the group consisting of promoting fibroblast growth, promoting hyaluronic acid production and contracting a collagen gel, or a derivative or salt of the peptide is useful as an active ingredient of an anti-aging agent.
Claims14
A peptide consisting of a partial sequence of an amino acid sequence ELKLIFLHRLKRLRKRLKRK (SEQ ID NO:
- 1) and having one or more effects selected from the group consisting of promoting fibroblast growth, promoting hyaluronic acid production and contracting a collagen gel, or a derivative or salt of the peptide,
- the partial sequence consisting of 4 to 10 contiguous amino acids of the amino acid sequence,
- the derivative having a modification selected from C-terminal amidation or esterification, protection of an N-terminal amino group with a protecting group, protection of a substituent on an amino acid side chain in the molecule with a protecting group, a combination of C-terminal amidation or esterification and protection of an N-terminal amino group with a protecting group, a combination of C-terminal amidation or esterification and protection of a substituent on an amino acid side chain in the molecule with a protecting group, a combination of protection of an N-terminal amino group with a protecting group and protection of a substituent on an amino acid side chain in the molecule with a protecting group, and a combination of C-terminal amidation or esterification, protection of an N-terminal amino group with a protecting group and protection of a substituent on an amino acid side chain in the molecule with a protecting group.
9-13. (canceled)
Dependencies are inferred from the claim text.