Nanomaterials for the integration of soft into hard tissue
AssigneeNortheastern University
InventorsDaniel J. Hickey, Thomas J. Webster, Batur Ercan
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Abstract
Nanocomposite materials are provided for attaching soft tissue to hard tissue of a mammalian subject. The materials include a biodegradable polymer network suffused with mineral nanoparticles. The nanocomposite materials have a surface structure that promotes the infiltration, adhesion and proliferation of cells such as osteoblasts and fibroblasts, and are useful to reconstruct enthesis tissue, such as a tendon bone insertion. Devices containing the nanocomposites and methods for implantation of the devices at a tendon-bone interface or ligament-bone interface are provided for reconstructive surgery.
Claims33
A composite material comprising a biodegradable polymer matrix, a plurality of MgO nanoparticles embedded in the matrix, and a plurality of hydroxyapatite nanoparticles embedded in the matrix.
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