Intrinsic raman spectroscopy
AssigneeMassachusetts Institute of Technology
InventorsKate Bechtel, Wei-Chuan Shih, Michael Feld
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Abstract
The present invention relates to systems and methods for the measurement of analytes such as glucose. Raman and reflectance spectroscopy are used to measure a volume, of material such as a blood sample or tissue within a subject and determine a concentration of a blood analyte based thereon. The present invention further relates to a calibration method, constrained regularization (CR), and demonstrates its use for analyzing spectra including, for example, the measurement glucose concentrations using transcutaneous Raman spectroscopy.
Claims16
The Raman spectral measurement system comprising a processing system connected to a detector such that the processing system receives Raman data and reflected light data, the system processing the Raman data and reflected light data to provide spectral data indicating a concentration of analyte in the region of material.
A method for analyzing a spectrum comprising:
- providing a spectrum to be analyzed;
- and
- applying a transformation to the spectrum, the transformation including a spectral constraint.
A method of analyzing a spectrum to measure a blood analyte comprising:
- processing a Raman spectrum of a material containing a blood analyte with a reflectance spectrum of the material to provide a processed spectrum.
Dependencies are inferred from the claim text.