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US 2016/0097938 A1Published application
Silicone hydrogel lenses with water-rich surfaces
AssigneeNovartis AG
InventorsYongxing Qiu, John Dallas Pruitt, Sibichen J. Thekveli, Robert Carey Tucker, Jared Nelson
Life of this patent
Estimating the term…
Abstract
The invention is related to a hydrated silicone hydrogel contact lens having a layered structural configuration: a lower water content silicone hydrogel core (or bulk material) completely covered with a layer of a higher water content hydrogel totally or substantially free of silicone. A hydrated silicone hydrogel contact lens of the invention possesses high oxygen permeability for maintaining the corneal health and a soft, water-rich, lubricious surface for wearing comfort.
Claims21
1-64. (canceled)
A hydrated silicone hydrogel contact lens, comprising:
- a silicone hydrogel material which is obtained by copolymerization of a polymerizable composition comprising at least one silicone-containing vinylic monomer or at least one silicone-containing vinylic macromer or at least one silicone-containing prepolymer having ethylenically unsaturated groups;
- an anterior surface;
- and
- an opposite posterior surface,
- wherein the hydrated silicone hydrogel contact lens has an oxygen transmissibility of at least about 40 barrers/mm, a water content of from about 10% to about 75% by weight, an elastic modulus of from about 0.3 MPa to about 1.8 MPa, a surface wettability characterized by having an averaged water contact angle of about 80 degrees or less, and a surface hydrophilicity characterized by having a WBUT of at least about 10 seconds,
- wherein the hydrated silicone hydrogel contact lens has a cross-sectional surface-modulus profile which comprises, along a shortest line between the anterior and posterior surfaces on the surface of a cross section of the hydrated silicone hydrogel contact lens, an anterior outer zone including and near the anterior surface, an inner zone including and around the center of the shortest line, and a posterior outer zone including and near the posterior surface, wherein the anterior outer zone has an average anterior surface modulus (designated as SMAnt) while the posterior outer zone has an average posterior surface modulus (designated as SMPost), wherein the inner zone has an average inner surface modulus (designated as SMInner) wherein at least one of
- SM
- Inner
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- -
- SM
- Post
- _
- SM
- Inner
- _
- ×
- 100
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- %
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-
- and
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-
- SM
- Inner
- _
- -
- SM
- Ant
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- SM
- Inner
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- 100
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- %
- is at least about 20%, preferably at least about 25%, more preferably at least about 30%, even more preferably at least about 35%, most preferably at least about 40%, wherein the anterior and posterior outer zones covers a span of at least about 0.1 μm.
37 more elements
Dependencies are inferred from the claim text.