US 2016/0097785 A1Published application

Calibration method for photometry

AssigneeRoche Diagnostics Operations, Inc.

InventorsMartin Horstmann, Fridl Lang

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Abstract

A method for determining a physical property of a biological sample. The method comprises the steps of: acquiring a set of preliminary calibration signals of a first lot of a reagent using an automatic analyzer with a first photometry module; acquiring a reference set of signals of the first lot of the reagent using a calibration analyzer with a second photometry module; determining a set of module specific components by subtracting the reference set of signals from the preliminary calibration signals; acquiring a lot specific set of signals of a second lot of the reagent using the second photometry module; determining a lot calibration for the first photometry module using the set of module specific components and the lot specific set of signals; acquiring a measurement signal of the biological sample using the first photometry module and the second lot of the reagent; and determining a physical property of the biological sample using the measurement signal and the lot calibration.

Claims21

Dependent claims

A method for determining a physical property of a biological sample comprising:

acquiring a set of preliminary calibration signals of a first lot of a reagent using an automatic analyzer according to a calibration protocol, wherein the automatic analyzer acquires the preliminary calibration signals using a first photometry module;
acquiring a reference set of signals of the first lot of the reagent using a calibration analyzer according to the calibration protocol, wherein the calibration analyzer acquires the reference set of signals using a second photometry module;
determining a set of module specific components by subtracting the reference set of signals from the preliminary calibration signals;
acquiring a lot specific set of signals of a second lot of the reagent using the second photometry module according to the calibration protocol;
determining a lot calibration for the first photometry module using the set of module specific components and the lot specific set of signals;
acquiring a measurement signal of the biological sample using the first photometry module and the second lot of the reagent;
and
determining a physical property of the biological sample using the measurement signal and the lot calibration.

5 more elements

An analysis system comprising an automatic analyzer for analyzing a biological sample, wherein the automatic analyzer comprises:

a dispenser for dispensing a reagent into the biological sample,
a first photometric module for acquiring a measurement signal of the biological sample,
a memory for storing machine executable instructions, and
an analyzer controller for controlling the automatic analyzer,
and wherein execution of the machine executable instructions cause the analyzer controller to:
receive a set of module specific components;
receive a lot specific set of signals;
determine a lot calibration according to a calibration protocol for a second lot of a reagent using the set of module specific components and the lot specific set of signals;
dispense a portion of the second lot of reagent into the biological sample using the dispenser;
acquire the measurement signal of the biological sample using the first photometry module;
and
determine a physical property of the biological sample using the measurement signal and the lot calibration.

9 more elements

Dependencies are inferred from the claim text.

Facts

Application: 14/966,804Filed 11 Dec 2015
Priority: EP 13171586.412 Jun 2013
Published: 7 Apr 2016
Term ends: Not estimatedThe source records don’t support an estimate.

Classification10 codes

G01N 33/96
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing:…
G01J 1/0295
Details: constructional arrangements for removing other types of optical noise or for performing calibration
G01N 21/274
Using photo-electric detection ; circuits for computing concentration: calibration, base line adjustment, drift correction
G01N 21/75
Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light: systems…