Immunoassay for pyrrolidinophenones
AssigneeRandox Laboratories Limited
InventorsIvan McConnell, Peter Fitzgerald, Philip Lowry, Elouard Benchikh
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Abstract
The current invention provides an improved immunoassay for the detection and determination of pyrrolidinophenone based designer drugs in hair and biological fluids (urine, blood, and oral fluid). The generic immunoassay is underpinned by novel, sub-family-specific antibodies, which display surprising sensitivity. The invention further describes substrates comprising an antibody that is specific to compounds of the pyrrolidinophenone family. Also described are the novel immunogens from which the antibodies are derived and kits incorporating the antibodies of the current invention.
Claims22
-5. (canceled)
An antibody which is raisable from an immunogen of structure I:
- wherein:
- Y is a crosslinking group;
- and
- accm is an antigenicity-conferring carrier material.
An antibody that binds to an epitope of structure II:
- wherein:
- A is aryl;
- R3 is C1-C6 alkyl;
- and
- each R1 and R2 is independently —H, C1-C4 alkyl, C1-C4 alkoxy, hydroxy substituted C1-C4 alkyl, carboxy, halo, or hydroxy;
- or
- R1 and R2 join together to form an optionally substituted:
-14. (canceled)
-28. (canceled)
(canceled)
Dependencies are inferred from the claim text.