Method for diagnosis and prognosis of chronic obstructive pulmonary disease (copd)
AssigneeImperial Innovations Limited
InventorPaul Archibald KIRKHAM
Life of this patent
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Abstract
A method for aiding in categorising or determining prognosis in a subject with COPD, or in selecting a therapeutic strategy for a subject with COPD, or in monitoring disease progression or assessing effectiveness of a treatment regime for COPD, the method comprising the step of assessing the antibody response to carbonylated vimentin in a sample obtained from the subject. The method may further comprise the step of selecting a treatment regime making use of the information on the antibody response to carbonylated vimentin in the sample. The step of assessing of the antibody response to carbonylated vimentin may comprise the step of determining the ratio of IgG to IgM in the antibody response to carbonylated vimentin.
Claims14
A method for aiding in categorising or determining prognosis in a subject with COPD, or in selecting a therapeutic strategy for a subject with COPD, or in monitoring disease progression or assessing effectiveness of a treatment regime for COPD, the method comprising the step of assessing the antibody response to carbonylated vimentin in a sample obtained from the subject.
An agent which is specifically capable of use in assessing the antibody response to carbonylated vimentin in a sample, optionally a ratio of IgG (or IgG1) to IgM in said antibody response to carbonylated vimentin, for aiding in categorising or determining prognosis in a subject with COPD, or in selecting a therapeutic strategy for a subject with COPD, or in monitoring disease progression or assessing effectiveness of a treatment regime for COPD.
A method for treating a subject with COPD, the method comprising administering to the subject an anti-idiotypic antibody or antibody fragment directed to an anti-carbonylated vimentin antibody;
- or a non-complement-activating anti-carbonylated vimentin antibody or antibody fragment.
A screening method for identifying a compound likely to be useful in treating COPD, the method comprising the step of determining the effect of a test compound on antibody response to carbonylated vimentin, optionally a IgG:IgM ratio in said antibody response, in a sample from a subject receiving the test compound;
- and selecting a compound that positively modulates said antibody response, optionally reduces said IgG:IgM ratio, optionally from a high to a low level (as indicated above), or prevents or reduces an increase in said IgG:IgM ratio from a low level to a high level.
Dependencies are inferred from the claim text.