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AssigneeNodality, Inc.
InventorsWendy J. Fantl, Santosh K. Putta, Omar D. Perez, Helen L. Francis-Lang, Aileen C. Cohen
Estimating the term…
This invention is directed to methods and compositions for diagnosis, prognosis and for determining methods of treatment. The physiological status of cells present in a sample (e.g. clinical sample) can be used in diagnosis or prognosis of a condition (e.g. Chronic Lymphocytic Leukemia), in patient selection for therapy, to monitor treatment and to modify or optimize therapeutic regimens. The physiological status of a cell can be determined by comparing the intracellular status of one or more activation elements (e.g. the phosphorylation status of a signaling molecule) in a cell (e.g. a cancer cell) to that of another cell (e.g. a normal cell). The physiological status of a cell can be further classified by adding one or more modulators (e.g. an inhibitor or activator) to the cell in question. In some embodiments, the invention is directed to methods of determining a phenotypic profile of a population of cells.
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A method of treating an individual suffering from chronic lymphocytic leukemia (CLL) comprising treating the individual based on the outcome of a test comprising
A kit comprising
Dependencies are inferred from the claim text.