Materials and methods for assaying living cells
AssigneesUniversity of Maryland, College Park, University of Maryland, Baltimore
InventorsStuart Martin, Christopher M. Jewell, James I. Andorko, Elisabeth Lily Sooklal, Rebecca Whipple Bettes, Kristi Chakrabarti
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Abstract
The present invention provides a device for assaying living cells comprising a substrate, wherein the substrate comprises one or more tethering molecules which adhere to the substrate and are capable of interacting with cell membranes of the cells, wherein the cells maintain a free-floating, non-adherent character when bound to the one or more tethering molecules.
Claims34
A device for assaying living cells comprising a substrate, wherein the substrate comprises one or more tethering molecules which adhere to the substrate and are capable of interacting with cell membranes of the cells, wherein the cells maintain a free-floating, non-adherent character when bound to the one or more tethering molecules.
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A method of making a device for assaying living cells, comprising:
- i) coating a substrate with one or more layers of one or more materials that substantially inhibit the cells from adhering to the substrate;
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- ii) contacting the coated substrate with one or more tethering molecules which adhere to the substrate and are capable of interacting with cell membranes of the cells, wherein the cells maintain a free-floating, non-adherent character when bound to the one or more tethering molecules.
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Dependencies are inferred from the claim text.