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US 2016/0097739 A1Published application
System for Detection of Analytes
AssigneesAlveo Technologies, Inc., The Regents of the University of California
InventorsSumita Pennathur, Peter Joseph Crisalli, Ronald Phillip Chiarello
Life of this patent
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Abstract
Embodiments provide analyte detection systems for detecting the presence of one or more analytes in one or more samples. An exemplary detection system includes at least one channel for accommodating a sample and a sensor compound, the channel having a width and a length that is significantly greater in dimension than the width. An exemplary detection system includes an analyte detection circuit programmed or configured to detect one or more electrical properties along at least a portion of the length of the channel to determine whether the channel contains an analyte of interest.
Claims25
A detection system, comprising:
- a substrate, the substrate having at least one channel, the at least one channel having a length and a width, the length substantially greater than the width;
- a first port in fluid communication with a first end section of the at least one channel;
- a second port in fluid communication with a second end section of the at least one channel;
- a first electrode electrically connected at the first end section of the at least one channel and a second electrode electrically connected at the second end section of the at least one channel, the first and second electrodes electrically connected to their respective first and second end sections of the at least one channel to form a channel circuit, the channel circuit having electrical properties and configured such that when an electrically conductive fluid is present in the at least one channel, the electrically conductive fluid alters the electrical properties of the channel circuit;
- and
- an analyte detection circuit in electrical communication with the first and second electrodes, the analyte detection circuit including a measurement circuit in electrical communication with the first and second electrode, the measurement circuit having a measurement circuit output, the measurement circuit output including one or more values indicative of one or more electrical properties of the channel circuit, the analyte detection circuit including a memory in electrical communication with the measurement circuit output and configured to store the one or more values indicative of the one or more electrical properties of the channel circuit including at least a first value of an electrical property of the channel circuit and a second value of the electrical property of the channel circuit, the analyte detection circuit further including a comparison circuit in electrical communication with the memory and having as inputs the at least first and second values, the comparison circuit configured to provide a comparison circuit output based at least in part on the at least first and/or second values, the comparison circuit output indicative of whether an analyte is present in the at least one channel.
3 more elements
A detection system, comprising:
- a substrate, the substrate having at least one channel, the at least one channel having a length and a width, the length substantially greater than the width;
- a first port in fluid communication with a first end section of the at least one channel;
- a second port in fluid communication with a second end section of the at least one channel;
- a first electrode electrically connected at the first end section of the at least one channel and a second electrode electrically connected at the second end section of the at least one channel, the first and second electrodes electrically connected to their respective first and second end sections of the at least one channel such that when an electrically conductive fluid is present in the at least one channel, the electrically conductive fluid completes an electrical circuit between the first and second electrodes;
- and
- analyte detection circuitry in electrical communication with the first and second electrodes, the analyte detection circuitry configured to measure one or more electrical properties between the first and second electrodes, the analyte detection circuitry including a memory, the memory configured to store a measured electrical property value, the analyte detection circuitry further including a comparison circuit configured to detect presence of an analyte in the at least one channel based on the measured electrical property value.
3 more elements
A detection system, comprising:
- means for accommodating a fluid flow;
- means for introducing a fluid at a first terminal end of the means for accommodating the fluid flow;
- means for outputting the fluid at a second terminal end of the means for accommodating the fluid flow;
- means for detecting first and second values of an electrical property of the fluid between the first and second terminal ends of the means for accommodating the fluid flow;
- and
- means for determining whether an analyte is present in the fluid based on a difference between the first and second values of the electrical property.
3 more elements
Dependencies are inferred from the claim text.