Methods of making cocrystals
AssigneeAmri Ssci, LLC
InventorsMelanie Janelle Bevill, Christopher Scott Seadeek, Ekaterina V. Albert, Petinka I. Vlahova, Richard James Ely, Patricia Andres
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Abstract
Disclosed are processes for preparing cocrystals, including processes for scaling up of cocrystal formation, as well as scalable processes for preparing cocrystals. Also disclosed are processes for scaled-op preparation of pterostilbene, progesterone, p-coumaric, and minoxidil cocrystals. Minoxidil cocrystals, such as minoxidil:benzoic acid 1:1 monohydrate cocrystals are also disclosed herein.
Claims21
-79. (canceled)
A process for making a cocrystal of a compound and a coformer comprising combining the compound dissolved in a solvent solution with the coformer dissolved in the solvent solution wherein the solubilities of the compound and the coformer in the solvent solution are each of a value sufficiently similar to form a cocrystal of the compound and the coformer as a single crystal phase, and precipitating a cocrystal of the compound and the coformer from the solvent solution.
Dependencies are inferred from the claim text.