Genetic test to predict patient response to bone morphogenetic protein in arthrodesis
AssigneesThe Translational Genomics Research Institute, Orthopaedic Associates of Michigan
InventorsJeffrey TRENT, Clifford Barry JONES, Debra Lynn SIETSEMA
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Abstract
The present invention provides a method of predicting an increased likelihood of a complication associated with administration of a bone morphogenetic protein (BMP) to a subject in need of a spinal fusion surgery by detecting single nucleotide polymorphisms (SNPs) in the subject. Also provided are methods of treatment with a BMP based on the presence or absence of SNPs and kits for use in detecting the SNPs.
Claims21
A method of predicting an increased likelihood of a complication associated with administration of a bone morphogenetic protein (BMP) in a human subject in need of a spinal fusion surgery comprising the steps of:
- obtaining a sample from the human subject in need of the spinal fusion surgery;
- detecting in the sample the presence of one or a combination of two or more single nucleotide polymorphisms (SNPs) selected from the group consisting of a thymine at the polymorphic position of rs10733133 (SEQ ID NO:
- 1), a cytosine at the polymorphic position of rs1126933 (SEQ ID NO:
- 2), a thymine at the polymorphic position of rs2433031 (SEQ ID NO:
- 3), a guanine at the polymorphic position of rs6571751 (SEQ ID NO:
- 4), and a thymine at the polymorphic position of rs7318267 (SEQ ID NO:
- 5);
- and
- predicting the human subject with the one or combination of SNPs has an increased likelihood of experiencing a complication resulting from administration of a BMP compared to a human subject without the one or combination of SNPs.
A method of treating a human subject in need of a spinal fusion surgery comprising:
- obtaining a sample from the human subject in need of the spinal fusion surgery;
- detecting in the sample the absence of one or a combination of two or more SNPs selected from the group consisting of a thymine at the polymorphic position of rs10733133, a cytosine at the polymorphic position of rs1126933, a thymine at the polymorphic position of rs2433031, a guanine at the polymorphic position of rs6571751, and a thymine at the polymorphic position of rs7318267, wherein the absence of the one or combination of SNPs indicates a decreased likelihood of experiencing a complication associated with administration of a BMP compared to a human subject with the one or combination of SNPs;
- and
- administering a BMP to the human subject.
A method of treating a human subject in need of a spinal fusion surgery comprising:
- obtaining a sample from the human subject in need of a spinal fusion surgery;
- detecting in the sample the presence of one or a combination of two or more SNPs selected from the group consisting of a cytosine at the polymorphic position of rs10733133, a guanine at the polymorphic position of rs1126933, an adenine at the polymorphic position of rs2433031, an adenine at the polymorphic position of rs6571751, and a cytosine at the polymorphic position of rs7318267, wherein the presence of the one or combination of SNPs indicates a decreased likelihood of experiencing a complication associated with administration of a BMP compared to a human subject with the one or combination of SNPs;
- and
- administering a BMP to the human subject.
-25. (canceled)
Dependencies are inferred from the claim text.