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AssigneeKorea Research Institute of Bioscience and Biotechnology
InventorsJeong Ki MIN, Jongjin PARK, Kwang-Hee BAE, Sang Chul LEE, Yee Sook CHO
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The present invention relates to a composition for detecting the undifferentiated human pluripotent stem cells comprising an agent useful for measuring the level of Desmoglein 2 (Dsg 2) mRNA or the protein thereof, a kit for detecting the undifferentiated human pluripotent stem cells comprising the said composition, a method for detecting the undifferentiated human pluripotent stem cells containing the step of measuring the level of Desmoglein 2 mRNA or the protein thereof, a method for evaluating the differentiation of human pluripotent stem cells and thereafter for separating the undifferentiated human pluripotent stem cells, a method for reducing the undifferentiated status of human pluripotent stem cells by inhibiting the expression or activation of Desmoglein 2, and a monoclonal antibody binding specifically to human Desmoglein 2.
A method for detecting or eliminating undifferentiated human pluripotent stem cells comprising the step of measuring levels of Desmoglein 2 mRNA or the protein thereof in separated human pluripotent stem cells.
A method for separating undifferentiated human pluripotent stem cells comprising the following steps:
A monoclonal antibody specifically binding to Desmoglein 2 having a heavy chain variable region (VH) comprising the heavy chain CDR1 represented by SEQ. ID. NO:
Dependencies are inferred from the claim text.