Production of chemicals and fuels from biomass

A method of converting biomass to biomass-derived fuels and chemicals, the method comprising:

• providing a biomass feed stream comprising a solvent and a biomass component comprising cellulose, hemicellulose or lignin, wherein the solvent comprises one or more members selected from the group consisting of water, in situ generated C2+O2+ oxygenated hydrocarbons, recycled C2+O2+ oxygenated hydrocarbons, bioreforming solvents, organic solvents, organic acids, and a mixture thereof;
• catalytically reacting the biomass feed stream with hydrogen and a deconstruction catalyst at a deconstruction temperature and a deconstruction pressure to produce a product stream comprising a vapor phase, a liquid phase and a solid phase, the vapor phase comprising one or more volatile C2+O1-2 oxygenates, the liquid phase comprising water and one or more C2+O2+ oxygenated hydrocarbons, and the solid phase comprising extractives;
• separating the volatile C2+O1-2 oxygenates from the liquid phase and solid phase;
• and
• catalytically reacting the volatile C2+O1-2 oxygenates in the presence of a condensation catalyst at a condensation temperature and condensation pressure to produce a C4+ compound comprising a member selected from the group consisting of C4+ alcohol, C4+ ketone, C4+ alkane, C4+ alkene, C5+ cycloalkane, C5+ cycloalkene, aryl, fused aryl, and a mixture thereof.