QSOX1 as an Anti-Neoplastic Drug Target
AssigneeArizona Board of Regents, a body corporate of the State of Arizona Acting for and on behalf of Arizo
InventorsDouglas Lake, Benjamin Katchman
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Abstract
The present invention provides methods for tumor treatment by administering an inhibitor of quiescin sulfhydryl oxidase 1 (QSOX1), compositions comprising such inhibitors, and methods for identifying such inhibitors.
Claims48
A method for tumor treatment, comprising administering to a subject having a tumor an amount effective of an inhibitor of quiescin sulfhydryl oxidase 1 (QSOX1) expression and/or activity, or a pharmaceutically acceptable salt thereof, to treat the tumor.
An isolated nucleic acid comprising an antisense, siRNA, miRNA, and/or shRNA molecule having a nucleic acid sequence perfectly complementary to least 10 contiguous nucleotides of SEQ ID NO:1 or SEQ ID NO:2, or an RNA equivalent thereof.
A method for identifying candidate compounds for treating a tumor, comprising
- (a) contacting tumor cells capable of expressing QSOX1 with one or more candidate compounds under conditions suitable for expression of QSOX1;
- and
- (b) determining a level of QSOX1 expression and/or activity in the tumor cells and comparing to control;
- wherein a compound that decreases QSOX1 expression and/or activity in the tumor cells relative to control is a candidate compound for treating a tumor.
A method for prognosing a tumor, comprising
- (a) determining a QSOX1 expression level in a sample from a subject having a tumor;
- (b) comparing the QSOX1 expression level to control;
- and
- (c) prognosing the progression of the tumor in the subject.
A method for inhibiting tumor metastasis, comprising administering to a subject having a tumor an amount effective of an inhibitor of quiescin sulfhydryl oxidase 1 (QSOX1) expression and/or activity, or a pharmaceutically acceptable salt thereof, to inhibit metastasis of the tumor.
Dependencies are inferred from the claim text.