Binding members-513
AssigneeMedImmune, LLC
InventorsJAMIE IAIN CAMPBELL, DUNCAN JAMES COCHRANE, DONNA KIRSTY FINCH, MARIA ANASTASIA TERESA GROVES, DAVID CHRISTOPHER LOWE, SIMON CHARLES CRUWYS
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Abstract
This invention relates to binding members, especially antibody molecules, specific for interleukin 1 receptor 1 (IL-1R1). For example, isolated binding members specific for IL-1R1 which competes with IL-1 and IL-1Ra for binding to IL-1R1 and binds Il-1R1 with a KD of 10 pM or less when measured by Kinexa™. The binding members are useful for, inter alia, treatment of disorders mediated by IL-1R1 including rheumatoid arthritis, asthma and chronic obstructive pulmonary disease (COPD).
Claims15
1-25. (canceled)
An isolated antibody or fragment thereof specific for IL-R11 comprising a set of CDRs:
- HCDR1, HCDR2, HCDR3, LCDR1, LCDR2 and LCDR3 wherein:
- HCDR1 has the amino acid sequence of SEQ. ID. NO:
- 63;
- HCDR2 has the amino acid sequence of SEQ. ID. NO:
- 64;
- HCDR3 has the amino acid sequence of SEQ. ID. NO:
- 65;
- LCDR1 has the amino acid sequence of SEQ. ID. NO:
- 68;
- LCDR2 has the amino acid sequence of SEQ. ID. NO:
- 69;
- LCDR3 has the amino acid sequence of SEQ. ID. NO:
- 70.
An isolated antibody or fragment thereof that binds IL-1R1, comprising a heavy chain variable region (VH) comprising SEQ ID NO:
- 62 and a light chain variable region (VL) comprising SEQ ID NO:
- 67.
Dependencies are inferred from the claim text.