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US 2016/0096893 A1Published application
Anti-her2 antibodies and immunoconjugates
AssigneeGenentech, Inc.
InventorsXiaocheng Chen, Mark Dennis, Jagath Reddy Junutula, Gail Lewis Phillips, Thomas Harden Pillow, Mark X. Sliwkowski
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Abstract
The invention provides anti-HER2 antibodies and immunoconjugates and methods of using the same.
Claims76
An isolated antibody that binds to HER2, wherein the antibody comprises (a) HVR-H1 comprising the amino acid sequence of SEQ ID NO:15;
- (b) HVR-H2 comprising the amino acid sequence of SEQ ID NO:16;
- (c) HVR-H3 comprising the amino acid sequence of SEQ ID NO:17;
- (d) HVR-L1 comprising the amino acid sequence of SEQ ID NO:12;
- (e) HVR-L2 comprising the amino acid sequence of SEQ ID NO:13;
- and (f) HVR-L3 comprising the amino acid sequence of SEQ ID NO:14.
2 more elements
An isolated antibody that binds to HER2, wherein the antibody comprises a heavy chain comprising the sequence of SEQ ID NO:
- 19 and a light chain comprising the sequence of SEQ ID NO:
- 23.
An isolated antibody that binds to HER2, wherein the antibody comprises a heavy chain comprising the sequence of SEQ ID NO:
- 24 and a light chain comprising the sequence of SEQ ID NO:
- 18.
Dependencies are inferred from the claim text.