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US 2016/0096891 A1Published application
Anti-b7-h5 antibodies and their uses
AssigneesMedImmune, LLC, The Johns Hopkins University
InventorsLIEPING CHEN, SHENG YAO, LINDA LIU, SOLOMON LANGERMANN
Life of this patent
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Abstract
The present invention relates to antibodies and their antigen-binding fragments and to other molecules that are capable of immunospecifically binding to the B7-H5 ligand of the B7-H5:CD28H pathway, and to the uses of such molecules in the treatment and diagnosis of autoimmune disease, transplant rejection and other inflammatory diseases.
Claims50
An antibody or antigen binding fragment thereof comprising six complementarity determining regions (CDRs),
- wherein the CDRs comprise
- (1) the three light chain CDRs of SEQ ID NO:11 and the three heavy chain CDRs of SEQ ID NO:9, or
- (2) the three light chain CDRs of SEQ ID NO:15 and the three heavy chain CDRs of SEQ ID NO:13, and
- wherein the antibody or antigen binding fragment thereof binds to B7-H5.
1 more element
A humanized antibody or antigen binding fragment thereof comprising one or more human IgG4 constant domains and
- a light chain variable region comprising the amino acid sequence of SEQ ID NO:11, a heavy chain variable region comprising the amino acid sequence of SEQ ID NO:9, or
- a light chain variable region comprising the amino acid sequence of SEQ ID NO:15, a heavy chain variable region comprising the amino acid sequence of SEQ ID NO:13.
Dependencies are inferred from the claim text.