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US 2016/0096887 A1Published application
Folate Receptor 1 Antibodies and Immunoconjugates and Uses Thereof
AssigneeImmunoGen, Inc.
InventorsOlga AB, Daniel Tavares, Lingyun Rui, Gillian Payne, Viktor S. Goldmakher
Life of this patent
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Abstract
Novel anti-cancer agents, including, but not limited to, antibodies and immunoconjugates, that bind to human folate receptor 1 are provided. Methods of using the agents, antibodies, or immunoconjugates, such as methods of inhibiting tumor growth are further provided.
Claims31
1-127. (canceled)
An immunoconjugate having the formula (A)-(L)-(C), wherein:
- (A) is an antibody that specifically binds a human folate receptor, wherein the antibody comprises a heavy chain comprising the amino acid sequence of SEQ ID NO:6 and a light chain comprising the amino acid sequence of SEQ ID NO:
- 12 or SEQ ID NO:
- 13;
- (L) is a linker selected from the group consisting of:
- N-succinimidyl 4-(2-pyridyldithio)pentanoate (SPP);
- N-succinimidyl 4-(2-pyridyldithio)-2-sulfopentanoate (sulfo-SPP);
- N-succinimidyl 4-(2-pyridyldithio)butanoate (SPDB);
- N-succinimidyl 4-(2-pyridyldithio)-2-sulfobutanoate (sulfo-SPDB);
- N-succinimidyl 4-(maleimidomethyl)cyclohexanecarboxylate (SMCC);
- N-sulfosuccinimidyl 4-(maleimidomethyl)cyclohexanecarboxylate (sulfoSMCC);
- N-succinimidyl-4-(iodoacetyl)-aminobenzoate (SIAB);
- and N-succinimidyl-[(N-maleimidopropionamido)-tetraethyleneglycol]ester (NHS-PEG4-maleimide);
- and
- (C) is a cytotoxic agent;
- wherein (L) links (A) to (C).
12 more elements
An immunoconjugate having the formula (A)-(L)-(C), wherein:
- (A) is an antibody that specifically binds a human folate receptor, wherein the antibody comprises a heavy chain comprising the amino acid sequence of SEQ ID NO:6 and a light chain comprising the amino acid sequence of SEQ ID NO:12 or SEQ ID NO:13;
- (L) is a linker;
- and
- (C) is a cytotoxic agent selected from the group consisting of:
- maytansinoid, maytansinoid analog, benzodiazepine, taxoid, CC-1065, duocarmycin, calicheamicin, dolastatin, auristatin, tomaymycin, and leptomycin or a prodrug of the cytotoxic agent;
- wherein (L) links (A) to (C).
3 more elements
An immunoconjugate having the formula (A)-(L)-(C), wherein:
- (A) is an antibody that specifically binds a human folate receptor, wherein the antibody comprises a heavy chain comprising the amino acid sequence of SEQ ID NO:6 and a light chain comprising the amino acid sequence of SEQ ID NO:12;
- (L) is the linker N-succinimidyl 4-(2-pyridyldithio)-2-sulfobutanoate (sulfo-SPDB);
- and
- (C) is the cytotoxic agent N(2′)-deacetyl-N(2′)-(4-mercapto-4-methyl-1-oxopentyl)-maytansine (DM4);
- wherein (L) links (A) to (C).
2 more elements
An immunoconjugate having the formula (A)-(L)-(C), wherein:
- (A) is an antibody that specifically binds a human folate receptor, wherein the antibody comprises a heavy chain comprising the amino acid sequence of SEQ ID NO:6 and a light chain comprising the amino acid sequence of SEQ ID NO:
- 13;
- (L) is the linker N-succinimidyl 4-(2-pyridyldithio)-2-sulfobutanoate (sulfo-SPDB);
- and
- (C) is the cytotoxic agent N(2′)-deacetyl-N(2′)-(4-mercapto-4-methyl-1-oxopentyl)-maytansine (DM4);
- wherein (L) links (A) to (C).
3 more elements
Dependencies are inferred from the claim text.