Neutralizing molecules to influenza viruses
AssigneeSea Lane Biotechnologies, LLC
InventorsLawrence Horowitz, Ramesh Bhatt, Arun Kashyap
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Abstract
The present invention concerns methods and means for identifying, producing, and engineering neutralizing antibodies against influenza A viruses, and to the neutralizing antibodies produced. In particular, the invention concerns neutralizing antibodies against various influenza A virus subtypes, and methods and means for making such antibodies.
Claims96
A binding molecule that comprises one, two, or three hypervariable region sequences from a heavy chain selected from the group consisting of SEQ ID NO:7, SEQ ID NO:8, and SEQ ID NO:9, or a functionally active fragment thereof.
A binding molecule that comprises one, two, or three hypervariable region sequences from a heavy chain selected from the group consisting of SEQ ID NO:10, SEQ ID NO:11, and SEQ ID NO:12, or a functionally active fragment thereof.
A binding molecule comprising a heavy chain, the heavy chain comprising the amino acid sequence shown as SEQ ID NO:1, or a functionally active fragment thereof.
A binding molecule comprising a heavy chain, the heavy chain comprising the amino acid sequence shown as SEQ ID NO:
- 2, or a functionally active fragment thereof.
An antibody which binds essentially the same epitope as the epitope for an antibody comprising a heavy chain polypeptide comprising an amino acid sequence shown as SEQ ID NO:1;
- or a consensus or variant sequence based upon said amino acid sequence.
An antibody which binds essentially the same epitope as the epitope for an antibody comprising a heavy chain polypeptide comprising an amino acid sequence shown as SEQ ID NO:2;
- or a consensus or variant sequence based upon said amino acid sequence.
A neutralizing antibody or binding molecule binding to a hemagglutinin of an influenza A virus having the ability to infect humans neutralizing at least one isolate of an influenza A virus comprising a length-modified heavy chain loop.
An engineered antibody or binding molecule with reduced oxidative potential binding to a hemagglutinin of an influenza A virus having the ability to infect humans neutralizing at least one isolate of an influenza A virus comprising one or more substitutions for methionine in a heavy chain variable domain.
Dependencies are inferred from the claim text.