Human cytomegalovirus neutralizing antibodies and use thereof
AssigneeInstitute for Research in Biomedicine
InventorsAntonio LANZAVECCHIA, Annalisa MACAGNO
Life of this patent
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Abstract
The invention relates to neutralizing antibodies, and antibody fragments thereof, having high potency in neutralizing hCMV, wherein said antibodies and antibody fragments are specific for one, or a combination of two or more, hCMV gene UL products. The invention also relates to immortalized B cells that produce, and to epitopes that bind to, such antibodies and antibody fragments. In addition, the invention relates to the use of the antibodies, antibody fragments, and epitopes in screening methods as well as in the diagnosis, prevention, and therapy of disease.
Claims18
1-70. (canceled)
A composition comprising an antibody, or an antigen binding fragment thereof, comprising the CDR1, CDR2, and CDR3 sequences of the heavy and light chain variable region sequences set forth in SEQ ID NOs:
- 170 and 171, respectively, wherein the composition is in lyophilized form.
A composition comprising an antibody, or an antigen binding fragment thereof, comprising heavy chain variable region CDR1, CDR2, and CDR3 sequences set forth in SEQ ID NOs:
- 113, 161, and 162, respectively, and light chain variable region CDR1, CDR2, and CDR3 sequences set forth in SEQ ID NOs:
- 163, 149, and 164, respectively, wherein the composition is in lyophilized form.
Dependencies are inferred from the claim text.