Viscosity-Reducing Excipient Compounds for Protein Formulations
AssigneeReform Biologics, LLC
InventorsDavid S. Soane, Philip Wuthrich, Rosa Casado Portilla, Robert P. Mahoney, Mark Moody
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Abstract
The invention encompasses formulations and methods for the production thereof that permit the delivery of concentrated protein solutions. The inventive methods can yield a lower viscosity liquid formulation or a higher concentration of therapeutic or nontherapeutic proteins in the liquid formulation, as compared to traditional protein solutions.
Claims15
A liquid pharmaceutical formulation comprising a therapeutic antibody and viscosity-reducing amount of caffeine, wherein (i) the viscosity of the formulation is at least about 50% less than the viscosity of a control formulation and is less than about 50 cP and (ii) the formulation contains at least about 100 mg/mL of the antibody.
Dependencies are inferred from the claim text.