Peptide-Silica Hybrid Materials

A method comprising incorporating a peptide strand A in a silica material or a metal oxide by using a peptide conjugate of the following formula (I):

• wherein:
• A is a peptide fragment,
• X is a spacer group,
• Y1, Y2, Y3, identical or different, each independently represents a hydrogen atom, a halogen atom, or an OR2 radical wherein R2 represents a hydrogen atom, an aryl group or a saturated or unsaturated aliphatic hydrocarbon chain comprising from 1 to 6 carbon atoms optionally substituted by an aryl, halogen or hydroxyl group,
• n is an integer between 1 and 50,
• wherein:
• if the peptide conjugate of formula (I), wherein A is a linear peptide fragment, comprises only one Si carried by an X group on the alpha amine at the N-terminus of fragment A, then
• A is a peptide fragment selected from the group consisting of an antibiotic, an antimicrobial, an antifungal, an anti-inflammatory, a catalyst, a biological receptor ligand and an enzyme inhibitor, or
• Y1 is different from Y2 and/or Y3
• the peptide conjugate is not one of the following structures:
• H-YGGFLR-NH—CH2—CH2—CH2—Si(OH)3, H-YGGFLR-NH—CH2—CH2—CH2—Si(OH)2F or H-YGGFLR-NH—CH2—CH2—CH2—Si(OH)F2.