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US 2016/0096859 A1Published application
Arbekacin derivative, and production and use thereof
AssigneeMeiji Seika Pharma Co., Ltd.
InventorsHiroyasu MIWA, Hisashi KISHI, Toshiro SASAKI, Takashi MURATA, Makoto OYAMA, Nao SANO, Ayako ODAGIRI
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Abstract
It has been found that adding carbon dioxide or the like to a solution containing arbekacin free base makes it possible to produce arbekacin derivatives including arbekacin carbonate and carbamic acid of arbekacin. Moreover, it has been found that the arbekacin derivatives have a high stability, and that the use thereof enables efficient productions of highly-pure arbekacin free base and pharmaceutically acceptable salt thereof.
Claims10
A production method for a carbamic acid derivative of arbekacin represented by the following formula (2):
- [in the formula, at least one of R1, R2, R3, and R4 is COOH, while the rest represent H] and including arbekacin carbonate represented by the following formula (1):
- [in the formula, x represents 1 to 5], the production method comprising:
- (a) a step of adding any one of carbon dioxide, a carbonate, and a hydrogen carbonate to a solution containing arbekacin free base, thereby preparing a solution containing a carbamic acid derivative of arbekacin including arbekacin carbonate;
- (b) a step of precipitating the carbamic acid derivative of arbekacin including arbekacin carbonate in the solution;
- and
- (c) a step of separating the precipitated carbamic acid derivative of arbekacin including arbekacin carbonate.
3 more elements
Dependencies are inferred from the claim text.