Method of purifying idraparinux sodium
AssigneeAmphastar Pharmaceuticals, Inc.
InventorsJundong Meng, Yonggang Xu, Wencun Wang, Song Chen, Haoning Wang
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Abstract
A method for the purification of idraparinux sodium includes: passing a solution including a crude idraparinux sodium through a column including a sodium ion exchange resin to obtain a first mixture; passing a solution including the first mixture through a gel chromatogaphy column to obtain a second mixture; and precipitating a purified idraparinux sodium from a solution including the second mixture.
Claims27
A method for obtaining at least 99.0% pure idraparinux sodium comprising nonasodium methyl 2,3,4-tri-O-methyl-6-O-sulfonato-α-D-glucopyranosyl-(1→4)-2,3-di-O-methyl-β-D-glucopyranuronosyl-(1→4)-2,3,6-tri-O-sulfonato-α-D-glucopyranosyl-(1-di-O-methyl-α-L-idopyranuronosyl-(1→4)-2,3,6-tri-O-sulfonato-α-D-glucopyranoside, the method comprising:
- passing a solution comprising a crude idraparinux sodium through a column comprising a sodium ion exchange resin to obtain a first mixture;
- passing a solution comprising the first mixture through a gel chromatography column to obtain a second mixture;
- and
- precipitating a purified idraparinux sodium from a solution comprising the second mixture.
A method for obtaining at least 99.0% pure idraparinux sodium comprising nonasodium methyl 2,3,4-tri-O-methyl-6-O-sulfonato-α-D-glucopyranosyl-(1→4)-2,3-di-O-methyl-β-D-glucopyranuronosyl-(1→4)-2,3,6-tri-O-sulfonato-α-D-glucopyranosyl-(1→4)-2,3-di-O-methyl-α-L-idopyranuronosyl-(1→4)-2,3,6-tri-O-sulfonato-α-D-glucopyranoside, the method comprising:
- passing a solution comprising a crude idraparinux sodium through a gel chromatography column to obtain a first mixture;
- passing a solution comprising the first mixture through a column comprising a sodium ion exchange resin to obtain a second mixture;
- and
- precipitating a purified idraparinux sodium from a solution comprising the second mixture.
Dependencies are inferred from the claim text.