Substituted bicyclic heteroaryl compounds

A compound of Formula (I).

• or a pharmaceutically acceptable salt thereof, wherein:
• X is O and Y is N;
• Z is N:
• Q is:
• (i)
• or
• (ii) 9- to 10-membered bicyclic heteroaryl selected from
• wherein Ring A is a 5- to 6-membered aryl or heteroaryl fused ring;
• R1 is:
• (i) H, halo, C1-4fluoroalkyl, C1-6alkoxy, C1-4 fluoroalkoxy, —S(C1-4fluoroalkyl), —O(C1-4alkylenyl)O(C1-3alkyl), —O(CH2)1-4N(C1-3alkyl)2, —O(C3-6alkynyl), or —O(methylpiperidinyl);
• (ii) phenyl substituted with zero to 2 substituents independently selected from F, Cl, —CF3, and/or —OCH3;
• (iii) C3-6cycloalkyl, morpholinyl, thiazolyl, pyridinyl, pyridazinyl, or pyrazinyl;
• or
• (iv) —O(CH2)1-4Rx wherein Rx is imidazolyl, thiazolyl, phenyl, fluorophenyl, chlorophenyl, methoxyphenyl, naphthalenyl, or pyrazinyl;
• and
• R3 is:
• (i) F, Cl, C1-4alkyl, C1-4alkoxy, or C1-4fluoroalkoxy;
• (ii) C3-6cyclopropyl, morpholinyl, pyrazolyl, imidazolyl, or triazolyl;
• (iii) —O(CH2)1-4Ry wherein Ry is phenyl, morpholinyl, or pyridazinyl;
• (iv) pyrrolidinyl substituted with zero to 2 substituents independently selected from —CH3 and/or —OH;
• or
• (v) —NH2, —NH(C1-4alkyl), —NH(C2-3fluoroalkyl), or —NH(C3-6cycloalkyl).