Oridonin analogs, compositions, and methods related thereto

An oridonin derivative compound having the general formula of Formula IIb:

• where R3 and R4 are independently hydrogen, hydroxy, methyl, ethyl, C3-C5 alkyl, C1-C5 hydroxyalkyl, a substituted or unsubstituted aryl, or a substituted or unsubstituted heteroaryl;
• where R5, R6, and R7 are independently hydrogen, oxo, nitro, halo, mercapto, cyano, azido, amino, imino, azo, sulfonyl, sulfinyl, sulfo, thioyl, methyl, ethyl, hydroxyl, NR8R9, C1-C6 carboxyl, C1-C6 hydroxyalkyl, C1-C6 aldehyde, C2-C6 ketone, C1-C6 ester, C1-C6 alkyl, C1-C6 heteroalkyl, C1-C6 alkoxy, C1-C6 alkenyl, C1-C6 alkylsulfonyl, substituted or unsubstituted 3 to 8 membered cycloalkyl, substituted or unsubstituted 3 to 8 membered heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted triazole, substituted or unsubstituted 3 to 8 membered spiro-cycloalkyl, or substituted or unsubstituted 3 to 8 membered spiro-heterocycle, wherein R6 and R7 cannot be hydrogen when R5 is oxo;
• and
• R8 and R9 are independently hydrogen, oxo, nitro, halo, mercapto, cyano, azido, amino, imino, azo, sulfonyl, sulfinyl, sulfo, thioyl, methyl, ethyl, hydroxyl, C1-C6 carboxyl, C1-C6 hydroxyalkyl, C1-C6 aldehyde, C2-C6 ketone, C1-C6 ester, C1-C6 alkyl, C1-C6 heteroalkyl, C1-C6 alkoxy, C1-C6 alkenyl, C1-C6 alkylsulfonyl, substituted or unsubstituted 3 to 8 membered cycloalkyl, substituted or unsubstituted 3 to 8 membered heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted triazole, substituted or unsubstituted 3 to 8 membered spiro-cycloalkyl, or substituted or unsubstituted 3 to 8 membered spiro-heterocycle;
• wherein the A ring has no double bonds, a double bond between positions 1 and 2, or a double bond between positions 2 and 3.