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US 2016/0096843 A1Published application
Pyrazolo-pyrrolidin-4-one derivatives and their use in the treatment of disease
AssigneeNovartis AG
InventorsJutta BLANK, Simona COTESTA, Vito GUAGNANO, Heinrich RUEEGER
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Abstract
The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing the pyrazolo-pyrrolidin-4-one derivatives, and their use as BET inhibitors for the treatment of conditions or diseases such as cancer. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
Claims10
A compound of formula (I) or a pharmaceutically acceptable salt thereof,
- wherein
- A is
- B is
- C is selected from:
- R1 is selected from methyl and chloro;
- R2 is selected from chloro and fluoro;
- R3 is selected from methyl and cyclopropyl;
- and R4 is selected from H;
- (C1-C4)alkyl optionally substituted by —OH or —O—(C1-C4)alkyl;
- cyclopropyl;
- or
- R3 is
- and R4 is selected from H;
- (C1-C4)alkyl optionally substituted by —OH or —O—(C1-C4)alkyl;
- and cyclopropyl;
- R5 is H;
- R6 is —O—(C1-C4)alkyl;
- R7 is selected from H and methoxy;
- and * indicates the point of attachment to the remainder of the molecule.
16 more elements
-12. (canceled)
Dependencies are inferred from the claim text.