Tank-binding kinase inhibitor compounds

A compound of formula (I):

• wherein,
• A is C6-10 aryl or 5-10 membered heteroaryl;
• X1 is CR1 or N;
• R1 is selected from the group consisting of H, C1-6 alkyl, C1-6 haloalkyl, —NRaRb, halogen, —CN, and —ORa;
• R2 is selected from the group consisting of H, hydroxyl, C1-6 alkyl, C1-6 heteroalkyl, —NRaRb, halogen, —C(O)Ra, —C(O)ORa, —C(O)NRaRb, —OC(O)NRaRb, —NRaC(O)Rb, —NRaC(O)ORb, —S(O)0-2Rc, —S(O)2NRaRb, —NRaS(O)2Rb, C6-10 aryl, C3-10 cycloalkyl, 5-10 membered heteroaryl, 3-12 membered heterocyclyl and —O—R5, wherein each C1-6 alkyl, C1-6 heteroalkyl, C6-10 aryl, C3-10 cycloalkyl, 5-10 membered heteroaryl and 3-12 membered heterocyclyl is optionally substituted with from one to five R20 groups;
• or R1 and R2 are taken together to form a fused C6 aryl, 5-6 membered heteroaryl, 5-6 membered heterocyclyl or C5-6 cycloalkyl each optionally substituted with one to five R20 groups;
• R3 is selected from the group consisting of H, C1-6 alkyl, C1-6 heteroalkyl, —NRaRb, halogen, —C(O)Ra, —C(O)ORa, —C(O)NRaRb, —OC(O)NRaRb, —NRaC(O)Rb, —NRaC(O)ORb, —S(O)0-2Rc, —S(O)(Rc)═NRb, —S(O)2F, —S(O)2NRaRb, —NRaS(O)2Rb, —N3, —CN, —NO2, ˜0Ra, C6-10 aryl, C3-10 cycloalkyl, 5-10 membered heteroaryl and 3-12 membered heterocyclyl wherein each C1-6 alkyl, C1-6 heteroalkyl, C6-10 aryl, C3-10 cycloalkyl, 5-10 membered heteroaryl and 3-12 membered heterocyclyl is optionally substituted with 1-5 R20 groups;
• each R4 is independently selected from the group consisting of H, C1-6 alkyl, C1-6 heteroalkyl, C1-6 haloalkyl, C1-6 hydroxyalkyl, C2-6 alkenyl, C2-6 alkynyl, C6-10 aryl, C3-10 cycloalkyl, 5-10 membered heteroaryl and 3-12 membered heterocyclyl, —NRaRb, halogen, —C(O)Ra, —C(O)ORa, —C(O)NRaRb, —OC(O)NRaRb, —NRaC(O)Rb, —NRaC(O)ORb, —S(O)0-2Rc, —S(O)2NRaRb, —NRaS(O)2Rb, —N3, —CN, —NO2 and —ORa, wherein each C1-6 alkyl, C1-6 heteroalkyl, C6-10 aryl, C3-10 cycloalkyl, 5-10 membered heteroaryl and 3-12 membered heterocyclyl is optionally substituted with from one to five R20 groups;
• or R3 and one R4 are taken together to form a fused C6 aryl, 5-6 membered heteroaryl, 5-6 membered heterocyclyl or C5-6 cycloalkyl each optionally substituted with one to five R20 groups;
• R5 is H;
• or C1-6 alkyl, C1-6 haloalkyl, C6-10 aryl, 5-10 membered heteroaryl, C3-10 cycloalkyl, or 3-12 membered heterocyclyl, each of which is optionally substituted with from one to five R20 groups;
• n is 0-2;
• each R20 is independently C1-6 alkyl, C3-10 cycloalkyl, C1-6 heteroalkyl, 3-12 membered heterocyclyl, C6-10 aryl, 5-10 membered heteroaryl, halogen, oxo, —ORa, —C(O)Ra, —C(O)ORa, —C(O)NRaRb, —OC(O)NRaRb, —NRaRb, —NRaC(O)Rb, —NRaC(O)ORb, —S(O)0-2Ra, —S(O)(Rc)═NRb, —S(O)2NRaRb, —NRaS(O)2Rb, —N3, —CN, or —NO2, or two R20 groups can join together to form a fused, spiro or bridged C3-10 cylcloalkyl or 3-12 membered heterocyclyl;
• wherein each C1-6 alkyl, C3-10 cycloalkyl, C1-6 heteroalkyl, 3-12 membered heterocyclyl, C6-10 aryl, 5-10 membered heteroaryl is optionally substituted with from one to five halogen, C1-6 alkyl, C1-6 heteroalkyl, C1-6 haloalkyl, oxo, imino, —ORa, —C(O)Ra, —C(O)ORa, —C(O)NRaRb, —OC(O)NRaRb, —NRaRb, —NRaC(O)Rb, —NRaC(O)ORb, —S(O)0-2Ra, —S(O)2NRaRb, —NRaS(O)2Rb, —N3, —CN, or —NO2;
• each R21 is independently C1-6 alkyl, C3-10 cycloalkyl, C1-6 heteroalkyl, 3-12 membered heterocyclyl, C6-C10 aryl, 5-10 membered heteroaryl, hydroxyl, C1-6 alkoxy, amino, —CN, —C(O)H, —C(O)NH2, —C(O)NH(C1-6 alkyl), —C(O)N(C1-6 alkyl)2, —COOH, —C(O)C1-6 alkyl, —C(O)OC1-6 alkyl, or halogen;
• and
• each Ra and each Rb are independently H;
• or C1-6 alkyl, C2-6 alkenyl, C3-10 cycloalkyl, C1-6 heteroalkyl, 3-12 membered heterocyclyl, C6-10 aryl, 5-10 membered heteroaryl, each of which is optionally substituted with from one to five R21;
• or Ra and Rb together with the atoms to which they are attached form a 3-12 membered heterocyclyl optionally substituted with one to five R21 groups;
• each Rc is independently C1-6 alkyl, C2-6 alkenyl, C3-10 cycloalkyl, C1-6 heteroalkyl, 3-12 membered heterocyclyl, C6-10 aryl, 5-10 membered heteroaryl, each of which is optionally substituted with from one to five R21;
• or a pharmaceutically acceptable salt thereof.