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US 2016/0096821 A1Published application
Chiral Synthesis of Pyrrolidine Core Compounds en route to Neuronal Nitric Oxide Synthase Inhibitors
AssigneeNorthwestern University
InventorsRichard B. Silverman, Fengtian Xue
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Abstract
A chiral synthesis of pyrrolidine compounds en route to selective neuronal nitric oxide synthase inhibitors, and representative inhibitor compounds heretofore unattainable.
Claims8
A method of preparing a chiral pyrrolidine core compound, said method comprising:
- providing a racemic di-N-Boc-protected 3,4-trans-(aminopyridinyl)alkyl-substituted pyrrolidine alcohol;
- protecting said amino group with a Boc reagent, to provide a tri-Boc-protected pyrrolidine compound;
- and
- resolving said racemate by camphanic acid esterification, to provide separable diastereomers.
1 more element
Dependencies are inferred from the claim text.