T-type calcium channel inhibitor
AssigneesKinki University, Fuso Pharmaceutical Industries, Ltd.
InventorsAtsufumi KAWABATA, Hideaki MATSUDA, Fumiko SEKIGUCHI, Kazuya MURATA, Hiroyuki NISHIKAWA
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AssigneesKinki University, Fuso Pharmaceutical Industries, Ltd.
InventorsAtsufumi KAWABATA, Hideaki MATSUDA, Fumiko SEKIGUCHI, Kazuya MURATA, Hiroyuki NISHIKAWA
Estimating the term…
The present invention provides a T-type calcium channel inhibitor which is a compound represented by formula (1), a pharmaceutically acceptable salt of this compound or a solvate of this compound. The present invention also provides: this T-type calcium channel inhibitor; a pharmaceutical product containing this T-type calcium channel inhibitor; and a therapeutic agent or prophylactic agent for diseases, the effective action of which is a T-type calcium channel inhibitory action. (In formula (1), each of R1 and R2 independently represents H, —OH or —OR11, wherein R11 represents a C1-3 alkyl group; each of R3 and R4 independently represents H, —OH or —OR12, wherein R12 represents a C1-3 alkyl group; and each of R5 and R6 independently represents H, a halogen atom, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a phenyl group (which may be substituted by a C1-6 alkoxy group or a halogen atom), a —C1-3 alkyl-phenyl group (which may be substituted by a C1-6 alkyloxy group or a halogen atom) or a C10-50 prenyl group.)
A T-type calcium channel inhibitor, wherein the T-type calcium channel inhibitor is a compound represented by the formula (1):
(canceled)
A T-type calcium channel inhibitor, which is (2S)-5,7-dihydroxy-2,3-dihydro-2-(2,4-dihydroxyphenyl)-8-[(R)-5-methyl-2-(1-methylethenyl)-4-hexenyl]-4H-1-benzopyran-4-on e, (2S)-5,7-dihydroxy-2,3-dihydro-2-(2,4-dihydroxyphenyl)-6-[(R)-5-methyl-2-(1-methylethenyl)-4-hexenyl]-4H-benzopyran-4-one, (2S)-5,7-dihydroxy-2,3-dihydro-2-(4-hydroxyphenyl)-6-(3-methyl-2-butenyl)-4H-1-benzopyran-4-one or (2S)-5,7-dihydroxy-2-(3-hydoxy-4-methoxyphenyl)-2,3-dihydro-4H-chromen-4-one.
Dependencies are inferred from the claim text.