Treatment of cancer/inhibition of metastasis
OwnerMustafa Bilgin Ali Djamgozinventor
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Abstract
Substances and methods are disclosed for reducing or preventing metastatic behaviour in VGSC expressing cancer by the effect of at least reducing the persistent part of the voltage gated sodium channel current without eliminating the transient part. Inhibition of metastatic cell behaviours such as detachability, lateral motility, transverse migration and invasiveness is demonstrated using the known drugs ranolazine and riluzole.
Claims26
Ranolazine for reducing or preventing metastatic behaviour in VGSC expressing cancer.
Riluzole for reducing or preventing metastatic behaviour in VGSC expressing cancer without directly killing the cancer cells.
A substance for reducing or preventing metastatic behaviour in VGSC expressing cancer by the effect of at least reducing the persistent part of the voltage gated sodium channel current without eliminating the transient part.
A method of reducing or preventing metastatic behaviour in VGSC expressing cancer comprising administering ranolazine.
A method of reducing or preventing metastatic behaviour in VGSC expressing cancer, comprising administering riluzole without directly killing the cancer cells.
A method of reducing or preventing metastatic behaviour in VGSC expressing cancer by administering a drug having the effect of at least reducing the persistent part of the voltage gated sodium channel current without eliminating the transient part.
Dependencies are inferred from the claim text.