Methods of resolving racemic mixture to obtain (-)-huperzine a
AssigneeAmphastar Pharmaceuticals, Inc.
InventorsYonggang Xu, Hao Wei, Song Chen, Haoning Zhang
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Abstract
A method of resolving a racemic mixture of (±)-Huperzine A to (−)-Huperzine A includes: separating the (−)-Huperzine A from the racemic mixture of (±)-Huperzine A by chiral high performance liquid chromatography (HPLC), the chiral HPLC being performed utilizing a mobile phase including a solution including an alcohol and one selected from dichloromethane, trichloromethane, and a mixture thereof, and the chiral HPLC being performed utilizing a chiral stationary phase including a polysaccharide derivative.
Claims20
A method of resolving a racemic mixture of (±)-Huperzine A to (−)-Huperzine A, the method comprising:
- separating the (−)-Huperzine A from the racemic mixture of (±)-Huperzine A by chiral high performance liquid chromatography (HPLC),
- the chiral HPLC being performed utilizing a mobile phase comprising a solution comprising an alcohol and one selected from dichloromethane, trichloromethane, and a mixture thereof, and
- the chiral HPLC being performed utilizing a chiral stationary phase comprising a polysaccharide derivative.
Dependencies are inferred from the claim text.