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US 2016/0096806 A1Published application
2-Aminoquinoline-Based Compounds for Potent and Selective Neuronal Nitric Oxide Synthase Inhibition
AssigneeNorthwestern University
InventorsRichard B. Silverman, Maris A. Cinelli, Anthony V. Pensa
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Abstract
Various 2-aminoquinoline compounds as can be used, in vivo or in vitro, for selective inhibition of neuronal nitric oxide synthase.
Claims30
A compound of a formula
- wherein n is an integer selected from 1-2;
- m is an integer selected from 1-3;
- each R is selected from halo, alkyl, haloalkyl, alkoxy, cyano, amino, N-alkylamino, N,N-dialkylamino, aminealkyl, N-substituted and oxa-substituted aminealkyl moieties;
- o is an integer selected from 0-3;
- and R′ is selected from halo, alkyl, haloalkyl and cyano moieties, or a salt thereof.
2 more elements
A compound of a formula
- wherein n is an integer selected from 1-2;
- m is an integer from 2-3, providing where m is 3, n is 1;
- each of R1 and R2 is independently selected from H, halo, alkyl and cyano moieties;
- and R′ is selected from H and methyl moieties, or a salt thereof.
1 more element
A compound of a formula
- wherein X is selected from O and NH;
- Y is selected from CH and N;
- n is an integer selected from 1-2;
- m is an integer selected from 0-3;
- o is an integer selected from 0-3;
- and each R is independently selected from halo, alkyl, haloalkyl, alkoxy, cyano, amino, N-alkylamino, N,N-dialkylamino, aminealkyl, N-substituted and oxa-substituted aminealkyl moieties;
- and R′ is selected from halo, alkyl, haloalkyl and cyano moieties, or a salt thereof.
4 more elements
Dependencies are inferred from the claim text.