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US 2016/0096017 A1Published application
Extremely low duty-cycle activation of the cholinergic anti-inflammatory pathway to treat chronic inflammation
AssigneeSetPoint Medical Corporation
InventorsJacob A. LEVINE, Michael A. FALTYS
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Abstract
Described herein are systems and methods for applying extremely low duty-cycle stimulation sufficient to treat chronic inflammation using feedback to adjust the off times between stimulations. In particular, the feedback include an assessment of the level of inflammation by the patient or the healthcare provider, or by measure the level of an inflammatory analyte or biomarker, or by detecting nerve activity correlated with inflammation.
Claims18
A system for treating chronic inflammation in a subject, the system comprising:
- an implantable microstimulator configured to apply a low duty-cycle stimulation to a vagus nerve;
- and
- a controller adapted to set a dose regimen, wherein the dose regimen comprises a plurality of electrical stimulations to the vagus nerve that are separated by an adjustable off period that is determined at least in part on feedback received by the controller.
A method of treating chronic inflammation in a subject, the method comprising:
- applying a plurality of electrical stimulations to a vagus nerve using a microstimulator, wherein the electrical stimulations are separated by an adjustable off period;
- determining a level of inflammation suffered by the subject;
- and
- adjusting the adjustable off period between electrical stimulations based at least in part on the determined level of inflammation.
1 more element
Dependencies are inferred from the claim text.