Nasal delivery devices

A nosepiece unit for use with a nasal delivery device in delivering a substance to a nasal cavity of a subject by an exhalation air flow, the nosepiece unit comprising:

• a nosepiece for fitting to a nostril of the subject;
• and
• a container-containing member operatively connected to and in fluid communication with the nosepiece, the container-containing member including an elongate flow passage, a fluid inlet, and a fluid outlet;
• wherein the container-containing member is configured to house a substance-containing container which contains the substance to be delivered to the nasal cavity of the subject;
• and
• wherein a cross sectional opening of the fluid inlet is smaller than the cross sectional opening of the elongate flow passage forming a flow restriction.

A nasal delivery device for delivering substance to a nasal cavity of a subject, comprising:

• a housing;
• a nosepiece unit mounted at least partially within the housing, the nosepiece unit including a nosepiece for fitting to a nostril of the subject and a container-containing member operatively connected to and in fluid communication with the nosepiece, the container-containing member including an elongate flow passage, a fluid inlet, and a fluid outlet;
• and
• a mouthpiece through which the subject in use exhales to deliver an exhalation flow through the housing and into the nosepiece unit;
• wherein the container-containing member is configured to house a substance-containing container which contains a substance to be delivered to the nasal cavity of the subject via the exhalation flow, wherein a cross sectional opening of the fluid inlet is smaller than the cross sectional opening of the elongate flow passage thereby forming a flow restriction.

A nosepiece unit for use with a nasal delivery device configured to deliver a substance to a nasal cavity of a subject by an exhalation flow, the nosepiece unit comprising:

• a nosepiece for fitting to the nasal cavity of the subject;
• and
• a container-containing member in fluid communication with the nosepiece and configured to house a substance-containing container that contains the substance to be delivered to the nasal cavity of the subject;
• wherein the container-containing member includes a flow passage in which the substance-containing container is disposed and an inlet aperture in fluid communication with the flow passage;
• and
• wherein the exhalation flow of the subject flows through the inlet aperture and the flow passage of the container-containing member.

A nasal delivery device for delivering a substance to a nasal cavity of a subject, the delivery device comprising:

• a container-receiving unit comprising a chamber and a container-containing member slidingly fitted within the container chamber and configured to move between a first position and a second, operative position;
• the container-containing member comprising a flow passage and configured to house a substance-containing container in the flow passage, the substance-containing-container containing the substance to be delivered to the nasal cavity of the subject;
• the container-containing member also comprising an inlet at an upstream end of the flow passage and an outlet at a downstream end of the flow passage, and first and second apertures in a lateral wall thereof;
• a nosepiece unit including a nosepiece for fitting to the nasal cavity of the subject;
• a mouthpiece unit including a mouthpiece in fluid communication with the inlet through which the subject in use exhales so as to deliver an exhalation flow through the mouthpiece and the flow passage of the container-containing member, the exhalation flow configured to entrain substance from the substance-containing container;
• and
• a container-opening mechanism configured to open the substance-containing container when the substance-containing container is disposed in the container-containing member, wherein the container-opening mechanism comprises first and second piercing elements which are arranged to pass through the first and second apertures in the lateral wall of the container-containing member only when the container-containing member is in the second, operative position.