Labelled carboxylic acids and their uses in molecular imaging
OwnerEric O. Aboagye, Lisa Iddon +2inventors
InventorsEric O. Aboagye, Lisa Iddon, Federica Pisaneschi, Timothy H. Witney
Life of this patent
Estimating the term…
Abstract
The present invention pertains generally to the field of imaging compounds, and more specifically to certain 2,2-dialkyl radionuclide-labelled carboxylic acids suitable for PEWT, SPECT and/or DNP imaging. Also described are uses of such compounds in the imaging of, inter alia, cancer tumors, metastasis, Alzheimer's disease and multiple sclerosis.
Claims51
A composition comprising a tracer, wherein the tracer is a labelled 2,2-di-C1-4-alkylpropanoic acid, 2,2-di-C1-4-alkylbutanoic acid, 2,2-di-C1-4-alkylpentanoic acid, or the corresponding carboxylate, wherein the tracer is labelled with:
- a radionuclide and/or
- a label suitable for polarisation using dynamic nuclear polarisation (DNP).
(canceled)
A method of synthesising a composition comprising a compound of formula (II):
- the method comprising the step of treating a compound of formula (III)
- with a reagent comprising a radionuclide nucleophile to give a compound of formula (IV)
- wherein
- Q is a radionuclide or group comprising a radionuclide;
- CL is selected from [12C]carbon or [13C]carbon;
- and R1, R2 and R3 are independently C1-4alkyl.
Dependencies are inferred from the claim text.