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US 2016/0095944 A1Published application
Novel multimodal ct/optical agents
AssigneeUniversity Health Network
InventorsJinzi Zheng, David A. Jaffray, Christine Allen
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Abstract
The present application relates to compositions comprising an iodinated contrast agent and indocyanine green co-encapsulated inside a liposomal carrier, various uses thereof as well as methods for their preparation.
Claims30
A composition comprising an iodinated contrast agent and indocyanine green co-encapsulated inside a liposomal carrier.
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A method for the manufacture of a liposome composition comprising indocyanine green and an iodinated contrast agent, the method comprising:
- a) combining one or more neutral lipids, cholesterol and one or more PEGylated lipids with an organic solvent at a temperature of about 40° C. to about 80° C.;
- b) combining indocyanine green with a solution comprising the iodinated contrast agent at a temperature of about 20° C. to about 70° C.;
- c) mixing the combination from a) with the combination from b) under conditions to obtain multilamellar liposomes;
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- d) extruding the liposomes at a pressure of about 50 psi to about 1000 psi.
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Dependencies are inferred from the claim text.