Dasatinib and nonlinear configuration polyethylene glycol conjugate
AssigneeJenkem Technology Co., Ltd. (Tianjin)
InventorsJinliang WANG, Xuan ZHAO, Zhenguo WANG
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Abstract
A dasatinib and nonlinear configuration polyethylene glycol conjugate represented by formula I, wherein core is the core structure of a nonlinear configuration of polyethylene glycol, selected from a residue of pentaerythritol, methylglucoside, sucrose, diethylene glycol, propanediol, glycerol or polyglycerol removaed the hydrogen atom from the hydroxyl group; P is a polyethylene glycol residue with a number-average molecular weight of 300-60000 Da; X is selected from single bond, —CH2CO—, —CH2CH2OCO— or CH2CH2NHCO—; and i is selected from 3, 4, 6 or 8.
Claims12
A dasatinib and nonlinear configuration polyethylene glycol conjugate shown as formula I
- wherein Core is the core structure of the nonlinear configuration of polyethylene glycol, selected from residues of pentaerythritol, methylglucoside, sucrose, diethylene glycol, propanediol, glycerol or polyglycerol removed the hydrogen atom from the hydroxyl group;
- P is a polyethylene glycol residue with a number-average molecular weight of 300-60000 Da;
- X is selected from single bond, —CH2CO—, —CH2CH2OCO— or —CH2CH2NHCO—;
- and i is selected from 3, 4, 6 or 8.
Dependencies are inferred from the claim text.