Back to results
US 2016/0095932 A1Published application
Bone Targeted Therapeutics and Methods of Making and Using the Same
AssigneeMbc Pharma, Inc.
InventorsAlexander Karpeisky, Shawn Patrick Zinnen
Life of this patent
Estimating the term…
Abstract
The present invention provides novel bisphosphonate conjugates, pharmaceutical compositions comprising bisphosphonate conjugates and methods of using such analogs in the treatment of bone cancer, bone-related diseases, bone infection, bone inflammation, and diseases of the soft tissues surrounding bones.
Claims20
A bisphosphonate conjugate comprising:
- or a pharmaceutically acceptable acid addition salt thereof wherein,
- X is O;
- V is O or S;
- Y is a residue of anti-infective compound;
- R1 is selected from the group consisting of OH, SH, NH2, OZ, SZ, NZ, halogen, and H;
- R2 is selected from the group consisting of H, Z, and halogen;
- and
- Z is selected from the group consisting of alkyl, cycloalkyl, aryl, heteroaryl, and NH2.
5 more elements
A bisphosphonate conjugate comprising:
- or a pharmaceutically acceptable acid addition salt thereof wherein:
- Y is a residue of anti-infective compound;
- R1 is selected from the group consisting of OH, SH, NH2, OZ, SZ, NZ, halogen, and H;
- R2 is selected from the group consisting of H, Z, and halogen;
- and
- Z is selected from the group consisting of alkyl, cycloalkyl, aryl, heteroaryl, and NH2.
3 more elements
An anti-infective compound having the structure
- Y(L-A)n
- or a pharmaceutically acceptable acid addition salt thereof wherein:
- n=1-3;
- A comprises a bisphosphonate residue having the structure
- wherein
- R1 is selected from the group consisting of OH, SH, NH2, OZ, SZ, NZ, halogen, and H;
- R2 is selected from the group consisting of H, Z, and halogen;
- Z is selected from the group consisting of alkyl, cycloalkyl, aryl, heteroaryl, and NH2;
- L is a linker comprising the structure:
- where V is O or S;
- and
- Y is a residue of an anti-infective compound.
9 more elements
Dependencies are inferred from the claim text.