Compositions containing hc-ha complex and methods of use thereof
AssigneeTissuetech, Inc.
InventorsScheffer TSENG, Hua HE
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Abstract
Disclosed herein, in certain embodiments, is an HC•HA complex comprising hyaluronan and a heavy chain of IαI, wherein the transfer of the heavy chain of IαI is catalyzed by TSG-6. Further disclosed herein, in certain embodiments, is an HC•HA complex comprising hyaluronan and a heavy chain of IαI, wherein the transfer of the heavy chain of IαI is catalyzed by the TSG-6 like protein. Additionally, disclosed herein are methods of manufacturing said complex and methods of use thereof.
Claims12
A pharmaceutical composition, comprising
- a) reconstituted HC•HA (rcHC•HA) complex comprising hyaluronan (HA) and a heavy chain of IαI, wherein TSG-6 is not covalently associated with the complex;
- and
- b) a pharmaceutically-acceptable excipient.
An HC•HA (rcHC•HA) complex intermediate, comprising hyaluronan (HA) and a heavy chain of IαI, wherein HA is immobilized on a stationary support via HA Binding Protein (HABP) crosslinked to the stationary support.
Dependencies are inferred from the claim text.