Derivatisation of Granulocyte Colony-Stimulating Factor
AssigneeLipoxen Technologies Limited
InventorsSanjay Jain, Peter Laing, Gregory Gregoriadis
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Abstract
The present invention relates to a compound which is a polysaccharide derivative of GCSF, or of a GCSF like protein, wherein the polysaccharide is anionic and comprises between 2 and 200 saccharide units. The present invention also relates to pharmaceutical compositions comprising the novel compounds, and methods for making the novel compounds.
Claims21
1-23. (canceled)
A compound which is an amino-terminal polysaccharide derivative of granulocyte colony-stimulating factor (GCSF), wherein the polysaccharide is attached to the amino terminus of the GCSF, wherein the polysaccharide is anionic and comprises between 2 and 200 saccharide units and has a weight average molecular weight in the range of 2 to 200 kDA.
A compound of formula (I)
- wherein m is at least one;
- XB is B—XH wherein B is GCSF and XH is NH2 and is the N-terminal amine of the GCSF;
- L is
- GlyO is an anionic saccharide unit;
- wherein R1 is a difunctional organic radical selected from the group consisting of alkanediyl, arylene, alkarylene, heteroarylene and alkylheteroarylene, any of which may substituted by and/or interrupted by carbonyl, ester, sulfide, ether, amide and/or amine linkages.
Dependencies are inferred from the claim text.